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Side Effects

Juvéderm® injectable gel is generally well tolerated. Most side effects are mild to moderate in nature and their duration is short lasting (7 days or less). The most common side effects include, but are not limited to, temporary injection site reactions such as redness, pain/tenderness, firmness, swelling, lumps/bumps, bruising, itching, and discoloration. As with all skin injection procedures, there is a risk of infection.

JUVÉDERM® clinical trial results

A clinical study was performed in the US to compare JUVÉDERM® Ultra injectable gel and JUVÉDERM® Ultra Plus injectable gel with ZYPLAST® dermal filler (bovine-based collagen). In each study, subjects were followed for 24 weeks after administration with JUVÉDERM® injectable gel in one nasolabial fold and ZYPLAST® dermal filler in the other. For both studies, injection site responses were similar in duration and frequency for the JUVÉDERM® injectable gel and ZYPLAST® dermal filler treated sides, were usually mild or moderate in severity, did not require intervention, and lasted 7 days or less.

Clinical trial of JUVÉDERM® Ultra injectable gel and ZYPLAST® dermal filler (146 total subjects): Percentage of subjects who reported common injection site responses

Clinical Trial Chart

Clinical trial of JUVÉDERM® Ultra Plus injectable gel and ZYPLAST® dermal filler (144 total subjects): Percentage of subjects who reported common injection site responses

Clinical Trial Chart

Post-treatment considerations

Your healthcare professional will tell you what to expect following treatment with JUVÉDERM® injectable gel. You should ask your healthcare professional when makeup may be applied after your treatment.

You should avoid the following for at least 24 hours after treatment:

  • Strenuous exercise
     
  • Consumption of alcoholic beverages
     
  • Extended exposure to sun or heat

Exposure to any of the above may cause temporary redness, swelling, and/or itching at the injection sites. If there is swelling, you may need to place an ice pack over the swollen area. Be sure to report any redness and/or visible swelling that lasts for more than a few days or any other symptoms that cause you concern to your healthcare professional and/or contact Allergan Product Support at 1-877-345-5372.

Download these helpful materials:

JUVÉDERM® Ultra Patient Safety Information

JUVÉDERM® Ultra Plus Patient Safety Information

get adobe reader Note: These documents are provided in Adobe® Reader® format (PDF). To view PDF documents, you must have the Adobe® Reader® software installed on your computer. If you do not have Adobe® Reader®, download it from the Adobe Web site.

JUVÉDERM® is part of the Allergan portfolio of products and this is the JUVÉDERM® website. For information on BOTOX® Cosmetic, visit www.botoxcosmetic.com.

JUVÉDERM® Safety Information

*JUVÉDERM® is indicated for injection into the mid to deep dermis for correction of moderate to severe facial wrinkles and folds (such as nasolabial folds).

Important JUVÉDERM® Safety Information

JUVÉDERM® injectable gel (including JUVÉDERM® Ultra, JUVÉDERM® Ultra Plus, JUVÉDERM® Ultra XC, and JUVÉDERM® Ultra Plus XC) is indicated for correction of moderate to severe facial wrinkles and folds (such as nasolabial folds). Side effects were usually mild to moderate, lasting 7 days or less, and included temporary injection-site reactions such as redness, pain, firmness, swelling, and bumps. JUVÉDERM® is not for people with severe allergies. For more information, please click on the About Safety link at www.juvederm.com or call the Allergan Product Support line at 1-877-345-5372. JUVÉDERM® injectable gel is available by prescription only.

BOTOX® Cosmetic Important Information

Indication

BOTOX® Cosmetic is a prescription medicine that is injected into muscles and used to improve the look of moderate to severe frown lines between the eyebrows (glabellar lines) in adults younger than 65 years of age for a short period of time (temporary).

IMPORTANT SAFETY INFORMATION, INCLUDING BOXED WARNING

BOTOX® Cosmetic may cause serious side effects that can be life threatening. Call your doctor or get medical help right away if you have any of these problems any time (hours to weeks) after injection of BOTOX® Cosmetic:

  • Problems swallowing, speaking, or breathing, due to weakening of associated muscles, can be severe and result in loss of life. You are at the highest risk if these problems are pre-existing before injection. Swallowing problems may last for several months.

  • Spread of toxin effects. The effect of botulinum toxin may affect areas away from the injection site and cause serious symptoms including: loss of strength and all-over muscle weakness, double vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice (dysphonia), trouble saying words clearly (dysarthria), loss of bladder control, trouble breathing, trouble swallowing.

There has not been a confirmed serious case of spread of toxin effect when BOTOX® Cosmetic has been used at the recommended dose to treat frown lines.

Do not take BOTOX® Cosmetic if you: are allergic to any of the ingredients in BOTOX® Cosmetic (see Medication Guide for ingredients); had an allergic reaction to any other botulinum toxin product such as Myobloc® or Dysport™; have a skin infection at the planned injection site.

Tell your doctor about all your muscle or nerve conditions such as such as amyotrophic lateral sclerosis [ALS or Lou Gehrig's disease], myasthenia gravis or Lambert-Eaton syndrome as you may be at increased risk of serious side effects including severe dysphagia (difficulty swallowing) and respiratory compromise (difficulty breathing) from typical doses of BOTOX® Cosmetic.

Tell your doctor about all your medical conditions, including if you have: plans to have surgery; had surgery on your face; weakness of forehead muscles, such as trouble raising your eyebrows; drooping eyelids; any other abnormal facial change; are pregnant or plan to become pregnant (It is not known if BOTOX® Cosmetic can harm your unborn baby); are breast-feeding or plan to breastfeed (It is not known if BOTOX® Cosmetic passes into breast milk).

Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins and herbal products.

BOTOX® Cosmetic may cause loss of strength or general muscle weakness, or vision problems. If this happens, do not drive a car, operate machinery, or do other dangerous activities.

Other side effects of BOTOX® Cosmetic include: dry mouth, discomfort or pain at the injection site, tiredness, headache, neck pain, and eye problems: double vision, blurred vision, decreased eyesight, drooping eyelids, swelling of your eyelids, and dry eyes.

For more information refer to the Medication Guide or talk with your doctor.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see BOTOX® Cosmetic Full Product Information including Medication Guide.